The best toenail fungus treatment for 2024, according to dermatologists

Price: $9 per applicator/bottle | Active ingredient: Tolnaftate, 1% | Application: Apply twice a day (morning and night)

Fungi-Nail takes the prize for best overall toenail fungus treatment in part because it's easy to use and you can choose between formulations: the pen applicator to zero in on nail edges or the brush-on liquid or ointment when you need to cover a wider area. All three versions contain tolnaftate, a known fungus killer, says Dr. Danilo C. Del Campo, a board-certified dermatologist at Chicago Skin Clinic.

Tolnaftate is included in many products for fungal skin infections such as athlete's foot, jock itch and ringworm. Del Campo says it's best, however, to opt for a preparation designed for nails.

A big caveat — with this and all topical toe fungus products — is that the active ingredient may not reach where it's needed. Nails are hard, Garg points out, and a medication that's readily absorbed into the skin may fail to penetrate the nail plate and reach the tissue underneath.

Price: $17.50 for a 6-ounce jar | Active ingredients: Menthol, eucalyptus oil, thymol | Application: Apply with finger or cotton swab at least once a day

Yes, it's that ointment your mom rubbed onto your chest when you were sick as a kid. But both Del Campo and Garg say it just might improve the appearance of a mildly infected toenail. The menthol and eucalyptus oil that give Vicks its famous minty smell also have antifungal properties — as does a secondary ingredient called thymol, Garg notes.

In fact, according to a 2022 research review, there is some limited evidence that Vicks can help improve toenail fungus. One of the studies included in the review found that of 18 people, 15 saw their toenail fungus at least partially clear up after dabbing the affected area with Vicks at least once a day for a year. (Toenail fungus treatment is a long-haul process, the experts say.)

"I do suggest Vicks to certain patients," says Del Campo, who also cites the tactic as his grandmother's favorite remedy. It's cheap and low-risk, he notes, and it may be enough for some people.

Price: $25 for a 2-ounce bottle | Active ingredient: Undecylenic acid, 25% | Application: Brush on twice a day (morning and night)

Toelieva takes the top prize here because it's an economical choice with a maximum-strength concentration of undecylenic acid, or UA. The compound is derived from the castor oil plant, and it's one of the oldest known fungus-fighters, Del Campo notes. "Undecylenic acid provides an accessible option for managing fungal conditions without a prescription, backed by decades of use," he says. 

Still, the effectiveness of UA for toenail fungus varies widely, Del Campo says. One way to improve your odds, he says, is to use a product with a high-enough concentration of UA; another is to use it diligently. Toelieva has the first covered; the second is up to you.

Price: $16 for a 16-ounce pouch | Active ingredient: Tea tree oil | Application: Soak feet for 15-20 minutes as needed

Here's a foot soak with a lot going for it — it offers the fungus-fighting properties of tea tree oil and eucalyptus oil, which some research suggests are helpful for toenail fungus infections that have not reached the tissue under the nail. The soak also offers bonus skin-soothers like Epsom salt and chamomile oil. Plus, pampering your whole foot, not just your nail, may help relieve symptoms of athlete's foot, which often goes hand in hand with toenail fungus. In fact, toenail fungal infections often begin as athlete's foot: As Adigun puts it, "You basically 'catch' the infection from yourself."

One downside is that foot soaks are a bigger time commitment than other remedies — you have to mix the ingredients in water until they dissolve, then soak your feet for 15 to 20 minutes. In addition, overdoing Epsom salt soaks can dry out or irritate your skin.

Price: $16 for a 1-ounce tube | Active ingredient: Terbinafine hydrochloride, 1% | Application: Apply once or twice a day

Lamisil is known for its ability to vanquish athlete's foot and jock itch, thanks to its active ingredient, terbinafine, a highly potent antifungal. In fact, when it comes to toenail fungus, oral prescription terbinafine is considered the most effective treatment. That said, the terbinafine in topical antifungals doesn't have the same effect because it's acting from the outside, where (once again) the issue is whether it can penetrate the nail and get where it needs to go.

At the same time, there is research suggesting that topical terbinafine — though at a hefty concentration of 10% — can effectively kill toenail fungus with a low risk of side effects. In general, Garg says, it's a matter of weighing risks and benefits: Oral drugs for toenail fungus are most effective but can have side effects and interact with other medications, so some people may prefer (or need) topical treatment. If you're jumping on the problem early, it's reasonable to reach for an OTC product first, Garg says.

Price: $19 for a 1-ounce bottle | Active ingredients: Tea tree oil, oregano oil | Application: Apply once or twice per day

This simple brush-on blend stands out for its combination of active ingredients — tea tree and oregano oil — which have been tested in a few small clinical trials. One study published in 2020 looked at the effects of an oil blend containing tea tree, oregano, lime and vitamin E: Of 20 participants who applied the oil daily for six months, 15 were cured — that is, the fungus was gone and their nails looked healthy.

Del Campo and Garg say tea tree oil has antifungal properties and that it's worth a shot for mild cases of toenail fungus. While tea tree oil can cause skin irritation, it's a low-risk ingredient, Garg says.

Price: $22 for a .34-ounce container | Active ingredient: Tolnaftate, 1% | Application: Apply twice a day (morning and night)

We like the way this 2-for-1 partners tolnaftate with a nail repair solution. Let's face it: You want an antifungal that works, but you also want that unsightly nail to look better while you're waiting. Opti-Nail promises to help. Step one is to apply the nail repair liquid, which contains lactic acid, glycerin and other ingredients designed to brighten the nail. Then, you brush the tolnaftate solution on top. Both products are housed in one handy pen that makes application easy and mess-free. That said, you end up getting a relatively small amount of the antifungal treatment for the price. 

Price: $19 for 14 patches | Active ingredient: None | Application: Wear once a day for 6-8 hours

These patches are easy to apply (and despite the name, you can wear them during the day if you prefer). It's important to stress that they contain no antifungal medication. The manufacturer says the ingredients — including glycerin and tartaric acid — can help fungus-damaged toenails look better by hydrating and exfoliating the area. Consider these an add-on to whatever else you're doing to battle your fungal infection.

Price: $14 for 12 packets | Active ingredient: Aluminum acetate | Application: Soak feet for 15-30 minutes, up to three times a day

Experts stress that if your toe hurts, you should see a doctor. "Toenail fungus should not hurt," Adigun says. If there's pain, that could mean there's something else going on, like a bacterial infection. And sometimes what looks like toenail fungus is actually a different animal altogether, Del Campo notes: The skin condition psoriasis, for example, sometimes appears in the nails first.

That said, if you're having minor skin irritation — whether from a topical antifungal or a bout of athlete's foot — Del Campo says Domeboro foot soak is a time-honored soother. The brand has been kicking for over 60 years, and the benefits of the active ingredient, aluminum acetate, have been recognized for even longer. "Sometimes the old stuff works," Del Campo says.

The tactic does take some effort — dissolving the powder into water, then soaking your feet for up to a half hour, multiple times a day. Somewhat paradoxically, aluminum acetate can also end up causing skin irritation for some people, so ease into the treatment and work up to three soaks per day.