| C | 10-day-dl (Contreras left Tuesday's (May 7th) game with an arm injury and did not return.) | |
| P | 15-day-dl (The St. Louis Cardinals placed RHP Giovanny Gallegos on the 15-day injured list with a shoulder injury.) | |
| P | 15-day-dl (The St. Louis Cardinals placed LHP Steven Matz on the 15-day injured list.) | |
| P | 60-day-dl (The St. Louis Cardinals placed LHP Riley O'Brien on the 15-day injured list with a right forearm flexor strain.) | |
| P | 15-day-dl (The St. Louis Cardinals placed RHP Keynan Middleton on the 15-day injured list.) | |
| SS | 60-day-dl (The St. Louis Cardinals transferred INF Tommy Edman to the 60-day injured list.) | |
| P | 60-day-dl (The St. Louis Cardinals transferred LHP Drew Rom to the 60-day injured list.) | |